BE got " Chinese crowd 2 researches that the diabetes easy feeling gene fixed position and blood sugar regulate related gene" that the title, concord hospital in Peking and national south, northern research center of the gene set of the mankind together participate by square blessing virtuous professor in the foundation medical science graduate school of the Chinese medicine department, hospital, pass to fasten 602 glycouria patient and his families, more than 400 members carry on in addition to the gene set out of sex chromosome scan analytical, at No.1 chromosome up, the precision positioned 5 easy feeling gene a point, and from among them of 2 order to look up the prkcz gene and uts 2 genes up the Shai, the first step is affirm for may be 2 diabetic candidate for election easy feeling gene.That result acquired the China medical science science and technology prize recently a wait a prize.
Square blessing virtuous professor's wait has won election to choose to have the house that the strong heredity incline to to fasten in the our country crowd since 1996, the fixed position and gram Long which carries on related gene study, totally acquire more than 100,000 gene analysis data, detection on the 1st of human body, on the 12th, on the 18th and No.20 there is 8 easy feeling gene on the chromosome point, uncommon is a No.1 chromosome up distribute more.Then again collected 28 houses to fasten, to on the 1st and No.20 chromosome ascend 6 through initial fine fixed position of easy feeling gene point, carry on many times repeat and verify.The research announces to public as a result, on these chromosomes, uncommon is the No.1 chromosome p bitter end 16.9 Li Mos of may contain many 2 feeling genes with easy diabetes inside heredity district.The characteristics that it intensively distributes, not only haven't seen up to the present in other diseases, but also have of is had especially by our country crowd.They continue to carry on fixed position and gram of the gene precision Long to the above-mentioned district and again make sure 8 snp point, discover that these snps are on diabetic's body of gene frequency with normal the person be obviously different, all variations all is conversion type.Through case check against a research detection, have 2 snp a point distinguish in the prkcz gene and uts 2 genes, hint these two kinds of genes may be the easy feeling gene of 2 diabetes very much.